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Health Testing Guide
Which tests are mandatory, how to spot responsible breeders — and what it costs when things go wrong.
For the Chiweenie we have compiled 4 mandatory and 27 recommended health tests, drawn from breed-club regulations, the University of PEI (CIDD), and OMIA — weighted by severity and heritability.
What this grade means
The Chiweenie combines the genetics of the Chihuahua and the Dachshund, carrying specific risks from both parent breeds. The elongated body structure of the Dachshund creates a high risk for intervertebral disc disease (canine IVDD), while the Chihuahua introduces predispositions to patellar luxation and heart conditions such as mitral valve disease. Skin issues like color dilution alopecia can also occur. Health-focused breeding relies on the targeted selection of parent dogs with robust spines, stable knee joints, and clear cardiac screenings to minimize the occurrence of these hereditary conditions.
Every breed is susceptible to certain inherited conditions. Just like humans, dogs inherit predispositions from their parents. Responsible breeders screen their breeding dogs for these conditions and make informed mating decisions to reduce the risk passed on to puppies.
No — but it's the strongest tool we have. Diet, exercise, environment, and genetics all contribute to whether a dog develops a condition. When breeders use the right tests to identify risk in potential parents, the likelihood of many conditions appearing in the puppies drops significantly.
There's no one-size-fits-all here. For the Chiweenie we track 4 mandatory tests plus 27 additional recommended ones. The specific tests and passing thresholds are detailed further below.
Keep in mind
Reliable screening tests still don't exist for many hereditary conditions, and tests for complex polygenic conditions are not always predictive of severity in the puppies. Even so, they're a powerful tool used by every responsible breeder.
There are two main types of health tests:
Screen the dog's DNA for known disease-causing mutations. Can be performed from puppyhood and give a binary result (clear / carrier / affected).
Clinical and imaging exams like X-ray, ultrasound, or ophthalmoscopy. They show how a predisposition actually manifests — usually only conclusive after 12–18 months.
We group breeding programs into three levels based on testing depth. Ask your breeder directly which level they meet.
A breeder at the Great level performs all mandatory tests plus 27 additional clinically recommended screenings that reduce risk in this breed.
In addition to mandatory tests:
Cleft palate
Allgemeine Fitness und Anatomie
A cleft palate is a congenital birth defect where the roof of the mouth fails to fuse properly during development in the womb. This failure leaves an abnormal opening between the oral cavity and the nasal passages. Because these two systems are directly connected, food, liquids, and air cannot be properly separated during swallowing.
Physisch
Dermoids
Augen
A dermoid is a benign, congenital growth where normal skin tissue, which can include hair follicles and glands, mistakenly develops in abnormal locations on the eye. This typically affects the cornea, which is the clear outer surface of the eye, or the conjunctiva, the pink membrane lining the eyelids. Because this misplaced skin tissue often grows hair, it causes constant irritation to the eye's surface.
Physisch
Keratoconjunctivitis sicca (KCS) - "dry eye"(KCS)
Augen
Keratoconjunctivitis sicca (KCS), commonly known as dry eye, is a chronic disease of the ocular system where the tear glands fail to produce enough natural tears. Without this protective moisture, the cornea (the clear surface of the eye) and surrounding tissues become dry, inflamed, and highly susceptible to painful damage.
Augen
Microphthalmia
Augen
Microphthalmia is a congenital developmental disorder of the visual system where one or both of a dog's eyeballs are abnormally small. This structural defect occurs during embryonic development and is often accompanied by other eye abnormalities, such as cataracts, which are cloudy areas in the lens of the eye. Because the eyeball itself is underdeveloped, the surrounding eyelids may also appear droopy or misaligned.
Optic nerve hypoplasia and micropapilla(ONH)
Augen
This condition involves the congenital underdevelopment of the optic nerve, known as optic nerve hypoplasia, or an abnormally small optic disc, called micropapilla. These structures are crucial parts of the eye's visual pathway, and their underdevelopment impairs the transmission of visual signals from the eye to the brain. It is a congenital defect of the visual system that is present from birth.
Augen
Progressive Retinal Atrophy (PRA)(PRA)
Augen
Progressive Retinal Atrophy (PRA) is an inherited eye disease that affects the retina, which is the light-sensitive layer of tissue at the back of the eye. In this condition, the specialized cells responsible for detecting light, known as photoreceptors, gradually degenerate and die. Because these cells cannot recover or be replaced, the disease slowly but inevitably leads to complete blindness.
Passing: N/N (frei) oder N/Träger / ECVO-Befund frei
Corneal dystrophy(CD)
Augen und Sehvermögen
Corneal dystrophy is an inherited eye disorder where abnormal, opaque materials like fats or calcium build up in the cornea, which is the clear outer layer of the eye. This accumulation typically affects both eyes and is non-inflammatory, meaning it does not cause immediate swelling or redness. Over time, these deposits can disrupt the smooth surface of the eye.
Augen
Cataract(HC)
Augen und Sehvermögen
A cataract is a progressive clouding of the lens inside the dog's eye, which is the clear structure that focuses light onto the retina at the back of the eye. When the lens becomes cloudy or opaque, it blocks light from entering, gradually impairing the dog's vision. If left untreated, this condition can eventually lead to complete blindness in the affected eye.
Augen
Pannus (Chronic Superficial Keratitis)(CSK)
Augen und Sehvermögen
Pannus, or chronic superficial keratitis, is an immune-mediated disease affecting the cornea, which is the clear outer surface of the eye. In this condition, the dog's immune system mistakenly attacks the cornea, causing blood vessels and dark pigment to grow across it. This process is worsened by exposure to ultraviolet (UV) light and can eventually block the dog's vision.
Augen
Primary Open-Angle Glaucoma(POAG)
Augen und Sehvermögen
Primary open-angle glaucoma is an inherited eye disease where the natural fluid inside the eye cannot drain properly. This fluid buildup causes a gradual increase in pressure within the eyeball, which eventually damages the optic nerve, the connection between the eye and the brain. Without management, this pressure leads to permanent blindness.
Augen
Cryptorchidism
Fortpflanzung
Cryptorchidism is a developmental condition of the male reproductive system where one or both testicles fail to descend normally into the scrotum. Instead, the undescended testicle remains trapped inside the abdomen or in the groin area. This failure to descend is a physical development issue rather than an active illness, but it alters how the reproductive organs develop.
Physisch
Color Dilution Alopecia (CDA)(CDA)
Haut und Fell
Color Dilution Alopecia is a genetic skin disorder that affects dogs with diluted coat colors, such as blue, fawn, or lilac. It is caused by an abnormal distribution of pigment within the hair shafts, which makes the hair brittle and prone to breaking. This structural weakness leads to progressive hair loss and leaves the skin more vulnerable to irritation.
Haut
Demodicosis / Demodectic mange
Haut und Fell
Demodicosis is a skin disease caused by an overgrowth of microscopic Demodex mites that naturally live inside a dog's hair follicles. While these mites are normally harmless, an inherited or acquired weakness in the immune system can allow them to multiply uncontrollably. This overgrowth leads to inflammation and damage to the skin barrier.
Haut
Histiocytoma
Haut und Fell
A histiocytoma is a non-cancerous (benign) skin growth that originates from Langerhans cells, which are part of the dog's immune system. These cells normally help protect the skin, but they can sometimes overgrow to form a small, harmless lump. In the vast majority of cases, these tumors are completely benign and will shrink and disappear on their own.
Haut
Ehlers-Danlos syndrome (Cutaneous asthenia)(EDS)
Haut und Fell
Ehlers-Danlos syndrome, also known as cutaneous asthenia, is an inherited connective tissue disorder that affects the skin and joints. It is caused by a genetic defect in collagen, which is the primary structural protein that provides strength and elasticity to tissues. Because of this defect, the skin lacks its normal structural integrity, making it unusually fragile, thin, and loose.
Haut
Pattern baldness
Haut und Fell
Pattern baldness is a cosmetic, genetically influenced condition affecting the skin and coat. It occurs when hair follicles gradually shrink over time, leading to localized hair loss. Because there is no underlying inflammation or infection, the skin itself remains healthy and unaffected.
Haut
Seborrhea
Haut und Fell
Primary seborrhea is an inherited skin disorder where the body's natural process of shedding and replacing skin cells happens much too quickly. This rapid cell turnover disrupts the skin's protective barrier and causes an overproduction of sebum, which is the natural oil produced by the skin's glands. As a result, the skin becomes either excessively greasy or very dry and flaky.
Haut
Mitral valve dysplasia(MVD)
Herz
Mitral valve dysplasia is a congenital heart defect where the mitral valve, which acts as a one-way gate on the left side of the heart, does not form correctly. This malformation prevents the valve from closing tightly, allowing blood to leak backward instead of pumping efficiently to the body. Over time, this leakage strains the heart muscle, which can lead to heart enlargement and eventual heart failure.
Ultraschall
Patent ductus arteriosus (PDA)(PDA)
Herz
Patent ductus arteriosus is a congenital heart defect where a normal fetal blood vessel connecting the aorta and the pulmonary artery fails to close shortly after birth. This failure allows blood to continuously recirculate through the lungs instead of flowing to the rest of the body, putting severe, permanent strain on the heart muscle. Over time, this volume overload causes the left side of the heart to enlarge and weaken.
Ultraschall
Pulmonary stenosis(PS)
Herz
Pulmonary stenosis is a congenital heart defect characterized by a narrowing of the pulmonary valve or the outflow tract leading from the heart to the lungs. This narrowing restricts blood flow, forcing the right side of the heart to work much harder to pump blood. Over time, this constant strain can lead to thickening of the heart muscle and potential heart failure.
Pyruvate kinase (PK) deficiency(PK)
Herz und Kreislauf
Pyruvate kinase (PK) deficiency is an inherited metabolic disorder affecting red blood cells, which lack a vital enzyme needed to produce energy. Without this enzyme, the red blood cells break down prematurely, leading to a severe shortage of oxygen-carrying cells, a condition known as chronic anemia. Over time, this constant cell destruction can cause secondary damage to organs like the liver and bone marrow.
DNA
Sick sinus syndrome(SSS)
Herz und Kreislauf
Sick sinus syndrome is a disorder of the heart's electrical system, specifically affecting the sinoatrial node, which acts as the heart's natural pacemaker. This malfunction causes the heart to beat too slowly, too quickly, or with long pauses, disrupting normal blood flow to the body. An echocardiogram (an ultrasound of the heart) is typically performed alongside electrical monitoring to rule out other structural heart diseases before proceeding with treatment.
Physisch
Congenital deafness(CHSD)
Nervensystem
Congenital deafness is a hereditary hearing loss present from birth that affects the inner ear's sensory cells, preventing sound signals from reaching the brain. It is often linked to specific genetic variants, such as those associated with certain coat patterns like merle or piebald, or breed-specific conditions like Early Onset Adult Deafness (EOAD). This genetic defect causes the vital blood supply to the inner ear to fail, leading to the permanent degeneration of the hearing nerve cells.
Physisch
Chiari-like malformation (CM) and syringomyelia (SM)(CM/SM)
Nervensystem
Chiari-like malformation is a structural neurological condition where the back of the skull is too small for the brain, forcing the lower part of the brain into the spinal canal. This displacement blocks the normal flow of cerebrospinal fluid, the protective liquid surrounding the brain and spine. Over time, the blocked fluid builds up and forms painful, fluid-filled cavities called syrinxes within the spinal cord, a secondary condition known as syringomyelia.
Roentgen
Hydrocephalus
Nervensystem
Hydrocephalus is a neurological condition affecting the brain and nervous system, commonly referred to as water on the brain. It occurs when cerebrospinal fluid, the natural protective liquid surrounding the brain, builds up abnormally inside the brain's cavities, known as ventricles. This accumulation creates harmful pressure on the surrounding brain tissue, which can impair normal brain function.
Roentgen
Urolithiasis
Nieren
Urolithiasis is the formation of mineral stones within the urinary tract, which includes the kidneys, bladder, and connecting tubes. These solid crystal clusters develop when minerals in the urine clump together instead of dissolving. Over time, these stones can irritate the sensitive lining of the urinary system or completely block the flow of urine.
von Willebrand's disease(vWD)
Stoffwechsel
Von Willebrand disease is an inherited bleeding disorder that affects the blood's ability to clot properly. It is caused by a deficiency or malfunction of the von Willebrand factor, a specific protein that helps blood platelets stick together to plug damaged blood vessels. Without enough of this functional protein, the clotting process is delayed, which can lead to excessive bleeding even from minor injuries.
Passing: N/N (frei) oder N/vWD1 (Träger)
These levels are a comparison framework, not an official certification. They help compare breeding programs at a glance.
A complete checklist with every mandatory and recommended test plus identity and rearing questions — take it with you.
Open the full checklistFor breeders
Machine-readable mating rules, minimum ages, scoring schemes, and what's required for HonestDog verification — as a printable guide.
Example rule — Patellar Luxation
Both parents must be Grad 0 (frei) oder Grad 1 or better.
We compile mandatory tests from official breed regulations and veterinary databases — and cross-check every uploaded certificate against the dog's profile using AI.
L1 = mandatory under breed-club regulations. L2 = recommended or clinically indicated. L3 = lower prevalence. Every assignment carries a source and confidence rating.
VDH breeding regulations, CIDD (University of PEI), OMIA (University of Sydney), curated veterinary input.
Uploaded certificates are AI-extracted and checked for date, result, and consistency with the dog's profile — with our team reviewing anything inconclusive.
4 tests are currently mandatory under the relevant breed-club regulations. The most common are Patellar Luxation (PL), Acanthosis Nigricans (AN), Intervertebral disc disease (IVDD). Every test must be completed before mating, and the result must fall within the threshold defined by the regulation.
Self-check
Answer 6 quick questions about your everyday life and see how well the Chiweenie fits you — including an honest cost estimate per month, per year, and across the dog's lifetime.
See breeders who have already uploaded their mandatory tests for verification.
View verified breeders