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Health Testing Guide
Which tests are mandatory, how to spot responsible breeders — and what it costs when things go wrong.
For the Neapolitan Mastiff we've compiled 3 core tests (2 of them required by Club für Molosser e.V.) and 3 additionally recommended tests, drawn from breed-club regulations, the University of PEI (CIDD), and OMIA — weighted by severity and heritability.
View verified breedersWhat this grade means
In the Neapolitan Mastiff, there are clear breed-specific risks for dilated cardiomyopathy as well as severe joint problems such as hip dysplasia (HD) and elbow dysplasia (ED), complemented by susceptibilities to skin fold dermatitis, ectropion / entropion, and prolapse of the gland of the third eyelid (Cherry Eye). The Club für Molosser e.V. therefore strictly mandates cardiological findings for dilated cardiomyopathy as well as X-ray examinations for HD (maximum HD C, mated only with A or B) and ED (maximum ED 2). A health-conscious breeder additionally pays attention to eyes and skin. Have the official findings for HD, ED, and dilated cardiomyopathy of the parent animals presented to you and ask about the status regarding ectropion / entropion.
Every breed is susceptible to certain inherited conditions. Just like humans, dogs inherit predispositions from their parents. Responsible breeders screen their breeding dogs for these conditions and make informed mating decisions to reduce the risk passed on to puppies.
No — but it's the strongest tool we have. Diet, exercise, environment, and genetics all contribute to whether a dog develops a condition. When breeders use the right tests to identify risk in potential parents, the likelihood of many conditions appearing in the puppies drops significantly.
There's no one-size-fits-all here. The core standard for the Neapolitan Mastiff covers 3 tests, 2 of them required by Club für Molosser e.V., plus 3 additional recommended tests. The specific tests and passing thresholds are detailed further below.
Keep in mind
Reliable screening tests still don't exist for many hereditary conditions, and tests for complex polygenic conditions don't always predict severity in the puppies. Even so, they're a powerful tool of responsible breeding.
There are two main types of health tests:
Screen the dog's DNA for known disease-causing mutations. Can be performed from puppyhood and give a binary result (clear / carrier / affected).
Clinical and imaging exams like X-ray, ultrasound, or ophthalmoscopy. They show how a predisposition actually manifests — usually only conclusive after 12–18 months.
We group breeding programs into three levels based on testing depth. Ask your breeder directly which level they meet.
A breeder at the Great level meets the Good level and performs 3 additional clinically recommended screenings that reduce risk in this breed.
In addition to Good:
Ectropion / Entropion
Augen
These are structural eyelid abnormalities affecting a dog's eyes. In cases of entropion, the eyelid rolls inward, causing the eyelashes or fur to rub painfully against the surface of the eyeball. In ectropion, the eyelid sags or rolls outward, leaving the sensitive inner lining of the eye exposed and unprotected.
Passing: clear
Third eyelid (nictitating membrane) abnormalities - "cherry eye"
Augen
A prolapse of the nictitating membrane gland, commonly called 'cherry eye,' occurs when the tear gland of the third eyelid slips out of its normal position. This gland is responsible for producing a significant portion of the eye's protective tear film. When the connective tissue holding it in place weakens, the gland protrudes, appearing as a red, fleshy mass in the inner corner of the eye.
Physical examination · Passing: clear
Fold dermatitis/pyoderma
Haut und Fell
Fold dermatitis, also known as intertrigo, is an inflammatory skin condition that occurs within deep skin folds. When skin rubs against skin, it traps moisture, heat, and debris, creating an ideal environment for bacteria and yeast to overgrow. This leads to localized skin infections, particularly in breeds with pronounced facial, lip, or tail folds.
Physical examination
Not health tests, but required for breeding: the club asks for these results too. They don't count toward the risks or the rating.
These levels are a comparison framework, not an official certification. They help compare breeding programs at a glance.
A complete checklist with every core-standard and additionally recommended test, plus identity and rearing questions — take it with you.
Open the full checklistFor breeders
Machine-readable mating rules, minimum ages, scoring schemes, and what's required for HonestDog verification — as a printable guide.
Example rule — Elbow Dysplasia
Both parents must be ED 0–2 or better.
We take mandatory tests from official breed regulations, build the recommended health standard from veterinary databases — and cross-check every uploaded certificate against the dog's profile using AI.
L1 = core standard: the club's required tests where its rules set them, otherwise the recommended health standard for the breed. L2 = additionally recommended or clinically indicated. L3 = lower prevalence. Every assignment carries a source and confidence rating.
VDH breeding regulations, CIDD (University of PEI), OMIA (University of Sydney), curated veterinary input.
Uploaded certificates are read by AI and checked for date, result, and consistency with the dog's profile — our team reviews anything inconclusive.
These hereditary conditions are currently classified as most relevant for the Neapolitan Mastiff: Elbow Dysplasia (ED), Hip dysplasia (HD), Dilated cardiomyopathy (DCM). The risk for a puppy depends primarily on whether both parents have been tested for these conditions and whether the results fall within breed-specific requirements.
Self-check
Answer 6 quick questions about your everyday life and see how well the Neapolitan Mastiff fits you — including an honest cost estimate per month, per year, and across the dog's lifetime.
See breeders who have already uploaded their health test results for verification.
View verified breeders