PNPLA8-associated neurodegeneration · Progressive degenerative myeloencephalopathy · PNPLA8-related myeloencephalopathy · PNPLA8-Enzephalopathie · Neurodegenerative disease PNPLA8-related · Hereditary ataxia (PNPLA8-related) · Progressive degenerative myeloencephalopathy in the Australian Shepherd
This is a severe inherited disease of the central nervous system, specifically affecting the brain and spinal cord. It is caused by a genetic mutation in the PNPLA8 gene, which leads to the progressive breakdown and loss of nerve tissue. As this nerve tissue degenerates, the brain's ability to communicate with the rest of the body is gradually lost.
Symptoms typically appear within the first year of life. Owners will first notice coordination issues, tremors, and weakness in the hind legs, which steadily worsens over time and eventually leads to paralysis.
There is no cure for this condition, and care is focused on keeping the dog comfortable. Managing the symptoms and diagnostic testing typically costs between 500 and 2,500 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Spine.