IBA57-related necrotizing myelopathy · Necrotizing myelopathy · IBA57 deficiency · IBA57-associated myelopathy · Nekrotisierende Myelopathie · Hereditary necrotizing myelopathy · ENM · Erbliche nekrotisierende Myelopathie
This condition, also known as hereditary necrotizing myelopathy (HNM), is a severe, recessively inherited disorder affecting the spinal cord. A genetic defect in the IBA57 gene leads to the progressive degeneration and death, or necrosis, of nerve tissue in the central nervous system. This loss of nerve tissue disrupts the communication between the brain and the rest of the body.
Symptoms typically appear in early puppyhood and include movement difficulties, weakness, and a loss of coordination in the limbs. These signs rapidly progress to complete paralysis.
There is no cure for this progressive condition, and veterinary care is focused on diagnostic confirmation and compassionate end-of-life care. The associated costs for supportive care and euthanasia typically range from 300 to 1000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Spine.