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Health Testing Guide
Which tests are mandatory, how to spot responsible breeders — and what it costs when things go wrong.
For the Great Dane we've compiled 1 test required by Deutscher Doggen Club 1888 e.V. and 10 additionally recommended tests, drawn from breed-club regulations, the University of PEI (CIDD), and OMIA — weighted by severity and heritability.
View verified breedersWhat this grade means
The Great Dane has an average lifespan of only around six to eight years, with life-threatening gastric dilatation-volvulus (GDV) being among the most frequent emergencies. Furthermore, severe conditions such as dilated cardiomyopathy, cervical spondylomyelopathy (Wobbler syndrome), and hip dysplasia (HD) burden the breed significantly. While the Deutsche Doggen Club 1888 e.V. mandates X-ray screening for hip dysplasia (HD) with a cut-off limit of HD A–C for breeding approval, responsible breeders additionally screen for heart diseases. Therefore, in addition to official HD findings, you must insist on seeing clear results for dilated cardiomyopathy and aortic stenosis, as well as clear eye certificates regarding cataracts and primary open-angle glaucoma.
Every breed is susceptible to certain inherited conditions. Just like humans, dogs inherit predispositions from their parents. Responsible breeders screen their breeding dogs for these conditions and make informed mating decisions to reduce the risk passed on to puppies.
No — but it's the strongest tool we have. Diet, exercise, environment, and genetics all contribute to whether a dog develops a condition. When breeders use the right tests to identify risk in potential parents, the likelihood of many conditions appearing in the puppies drops significantly.
There's no one-size-fits-all here. For the Great Dane, Deutscher Doggen Club 1888 e.V. requires 1 test for breeding approval, plus 10 additional recommended tests. The specific tests and passing thresholds are detailed further below.
Keep in mind
Reliable screening tests still don't exist for many hereditary conditions, and tests for complex polygenic conditions don't always predict severity in the puppies. Even so, they're a powerful tool of responsible breeding.
There are two main types of health tests:
Screen the dog's DNA for known disease-causing mutations. Can be performed from puppyhood and give a binary result (clear / carrier / affected).
Clinical and imaging exams like X-ray, ultrasound, or ophthalmoscopy. They show how a predisposition actually manifests — usually only conclusive after 12–18 months.
We group breeding programs into three levels based on testing depth. Ask your breeder directly which level they meet.
A breeder at the Great level meets the Good level and performs 10 additional clinically recommended screenings that reduce risk in this breed.
In addition to Good:
Gastric dilatation-volvulus(GDV)
Andere
Gastric dilatation-volvulus, commonly known as bloat, is a severe condition affecting the stomach and digestive system. It occurs when the stomach fills with gas and twists on itself, trapping the gas and blocking blood flow to vital organs. This twisting can rapidly lead to tissue damage and cardiovascular shock if not treated immediately.
X-ray
Megaesophagus(ME)
Andere
Megaesophagus is a disorder of the digestive system where the esophagus, the muscular tube connecting the throat to the stomach, becomes abnormally stretched and loses its muscle tone. Because these muscles can no longer contract to push food and liquid downward, meals become trapped in the tube. This trapped material is typically regurgitated, meaning it is passively cast back up before ever reaching the stomach.
X-ray
Cataract(HC)
Augen
A cataract is a progressive clouding of the lens inside the dog's eye, which is the clear structure that focuses light onto the retina at the back of the eye. When the lens becomes cloudy or opaque, it blocks light from entering, gradually impairing the dog's vision. If left untreated, this condition can eventually lead to complete blindness in the affected eye.
Eye examination · Passing: clear
Primary Open-Angle Glaucoma(POAG)
Augen
Primary open-angle glaucoma is an inherited eye disease where the natural fluid inside the eye cannot drain properly. This fluid buildup causes a gradual increase in pressure within the eyeball, which eventually damages the optic nerve, the connection between the eye and the brain. Without management, this pressure leads to permanent blindness.
Eye examination · Passing: clear
Cervical vertebral compressive myelopathy(CVCM)
Bewegungsapparat
Cervical vertebral compressive myelopathy, commonly known as Wobbler syndrome, is a condition affecting the spine where the spinal cord in the neck becomes pinched. This compression is caused by malformed neck vertebrae or slipping discs between the bones. Over time, the constant pressure damages the nerve pathways that carry signals from the brain to the limbs.
X-ray
Aortic valve stenosis(AS)
Herz
Aortic stenosis is a narrowing of the aortic valve in the heart, which controls blood flow from the main pumping chamber (the left ventricle) to the rest of the body. Because of this restriction, the heart muscle must work much harder to pump blood, which eventually causes the muscle wall to thicken abnormally. This is a severe cardiovascular condition that can strain the heart over time.
Passing: normal
Dilated cardiomyopathy(DCM)
Herz
Dilated cardiomyopathy (DCM) is a severe disease of the heart muscle where the heart's chambers become stretched and enlarged. This stretching thins the heart walls, making it difficult for the heart to pump blood effectively to the rest of the body. Over time, this decreased pumping ability can lead to fluid buildup in the lungs or abdomen.
Ultrasound · Passing: normal
Mitral valve dysplasia(MVD)
Herz
Mitral valve dysplasia is a congenital heart defect where the mitral valve, which acts as a one-way gate on the left side of the heart, does not form correctly. This malformation prevents the valve from closing tightly, allowing blood to leak backward instead of pumping efficiently to the body. Over time, this leakage strains the heart muscle, which can lead to heart enlargement and eventual heart failure.
Ultrasound · Passing: normal
Persistent right aortic arch (vascular ring anomaly)(PRAA)
Herz
This is a congenital abnormality of the cardiovascular system where a blood vessel near the heart fails to dissolve during development. This persistent vessel forms a tight ring around the esophagus, which is the tube that carries food from the mouth to the stomach. This ring constricts the esophagus, preventing solid food from passing through properly.
X-ray
Hypothyroidism
Stoffwechsel
Hypothyroidism is an endocrine disorder where the thyroid gland, located in the neck, fails to produce enough thyroid hormones. These hormones are essential for regulating the body's metabolic rate, which is the speed at which cells convert nutrients into energy. When hormone levels are too low, the dog's entire metabolism slows down, affecting multiple organ systems.
Body-fluid analysis
Not health tests, but required for breeding: the club asks for these results too. They don't count toward the risks or the rating.
These levels are a comparison framework, not an official certification. They help compare breeding programs at a glance.
A complete checklist with every core-standard and additionally recommended test, plus identity and rearing questions — take it with you.
Open the full checklistFor breeders
Machine-readable mating rules, minimum ages, scoring schemes, and what's required for HonestDog verification — as a printable guide.
Example rule — Hip dysplasia
Both parents must be HD A–C or better.
We take mandatory tests from official breed regulations, build the recommended health standard from veterinary databases — and cross-check every uploaded certificate against the dog's profile using AI.
L1 = core standard: the club's required tests where its rules set them, otherwise the recommended health standard for the breed. L2 = additionally recommended or clinically indicated. L3 = lower prevalence. Every assignment carries a source and confidence rating.
VDH breeding regulations, CIDD (University of PEI), OMIA (University of Sydney), curated veterinary input.
Uploaded certificates are read by AI and checked for date, result, and consistency with the dog's profile — our team reviews anything inconclusive.
Not across the board. But these traits can play a role in the Great Dane: Merle & double merle. Depending on the line, color or pairing, that is an extreme-breeding risk – what to look out for is explained on the linked pages.
Self-check
Answer 6 quick questions about your everyday life and see how well the Great Dane fits you — including an honest cost estimate per month, per year, and across the dog's lifetime.
See breeders who have already uploaded their health test results for verification.
View verified breeders