Central Core Disease · CCD · Zentralkern-Myopathie · Zentralkernmyopathie · RYR1-Myopathie · Inherited Myopathy of Great Danes · IMGD · Centronuclear Myopathy of Great Danes · BIN1-related Myopathy
Central core myopathy in Great Danes is an inherited muscle disorder that is now classified as a form of Centronuclear Myopathy (CNM). It is caused by a mutation in the BIN1 gene, which disrupts the internal structure of skeletal muscle cells and prevents them from contracting normally. This structural defect leads to generalized muscle weakness and dysfunction across the body.
Symptoms typically appear during puppyhood or early youth. Owners will notice significant muscle weakness, rapid fatigue during mild exercise, and a stiff, awkward, or wobbly way of walking.
There is no cure for this condition, meaning treatment is lifelong and focuses on supportive care, physiotherapy, and pain management. The expected lifetime cost for supportive veterinary care ranges from 1,500 to 6,000 EUR.
More conditions affecting the General / metabolic.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.