Hyperuricosuria(HUU)
Also known as: Hyperurikosurie · SLC2A9-associated hyperuricosuria · Harnsäure-Stoffwechselstörung · Urat-Urolithen · Uratsteine · …
Overview
What it is
Hyperuricosuria is an inherited metabolic disorder affecting the renal system, specifically how the kidneys process uric acid. Due to a genetic mutation, excess uric acid is excreted into the urine rather than being broken down. This high concentration can cause the acid to crystallize, leading to the formation of painful bladder or kidney stones, also known as uroliths.
How it presents
Symptoms typically appear in young to middle-aged dogs and include blood in the urine, frequent straining, or difficulty urinating. In severe cases, a complete urinary blockage can occur, which is a medical emergency.
Treatment
The condition is manageable with a lifelong special diet and high fluid intake, but surgical removal of stones may be necessary. Lifetime management and surgical costs generally range from €1,500 to €6,000.
How it's tested
HUU DNA-Test (Hyperurikosurie)(HUU)
Primary testDNA testHyperurikosurie (Harnsteinbildung). Pflicht bei Dalmatiner und einigen weiteren Rassen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
24 of 49 breeds
Black Russian TerrierMandatory testMandated by Klub für Terrier e.V.
BulldogRecommended standard
Exotic BullyRecommended standard
Giant SchnauzerMandatory testMandated by Pinscher-Schnauzer-Klub 1895 e.V.
KromfohrländerRecommended standard
Large MunsterlanderRecommended standard
Wirehaired VizslaRecommended standard
American BulldogAlso recommended
American BullyAlso recommended
American Hairless TerrierAlso recommended
American Pit Bull TerrierAlso recommended
Biewer TerrierAlso recommended
BoerboelAlso recommended
Cane CorsoAlso recommended
Cao Fila de Sao MiguelAlso recommended
Catahoula Leopard DogAlso recommended
Central Asian Shepherd DogAlso recommended
Chinese Crested DogAlso recommended
DalmatianAlso recommended
Danish-Swedish FarmdogAlso recommended
Dogo ArgentinoAlso recommended
Drentsche PatrijshondAlso recommended
East European ShepherdAlso recommended
Hungarian VizslaAlso recommended
Treatment cost
Estimated range of typical treatment costs. Actual costs depend on severity, clinic and region.
Frequently asked questions
What is Hyperuricosuria?
Hyperuricosuria is an inherited metabolic disorder affecting the renal system, specifically how the kidneys process uric acid. Due to a genetic mutation, excess uric acid is excreted into the urine rather than being broken down. This high concentration can cause the acid to crystallize, leading to the formation of painful bladder or kidney stones, also known as uroliths.
How is Hyperuricosuria tested?
Tests currently in our database: HUU DNA-Test (Hyperurikosurie), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Black Russian Terrier, Bulldog, Exotic Bully, Giant Schnauzer, Kromfohrländer, Large Munsterlander, Wirehaired Vizsla, American Bulldog.