CARMIL2 deficiency · Canine CARMIL2 immunodeficiency · Immundefekt durch CARMIL2-Mangel · Primary immunodeficiency CARMIL2-related · Primary Immunodeficiency with Pneumocystis Susceptibility, Type 2
This is an inherited disorder of the immune system caused by a genetic mutation in the CARMIL2 gene, which impairs the function of T-cells (a type of white blood cell essential for fighting infections). Without properly functioning T-cells, the dog's body cannot effectively defend itself against common environmental bacteria, viruses, and fungi. This leaves the animal highly susceptible to persistent and recurrent infections.
Affected dogs typically show symptoms in puppyhood, including slow-healing skin infections, chronic diarrhea, respiratory difficulties, and a general failure to thrive or grow at a normal rate.
There is no cure for this condition, meaning affected dogs require lifelong supportive care, including frequent courses of antibiotics and specialized veterinary management. Management is highly demanding, with estimated lifetime treatment costs ranging from 2,000 to 12,000 EUR.
More conditions affecting the General / metabolic.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.