TP53-associated cancer · Li-Fraumeni-like syndrome · TP53 hereditary cancer · TP53-assoziierter Krebs · TP53 tumor suppressor deficiency · Cancer, TP53-related
This condition is an inherited predisposition to cancer caused by a mutation in the TP53 gene. This gene normally acts as a tumor suppressor, meaning it produces a protein that regulates cell division and prevents damaged cells from multiplying. Without this functioning protective system, dogs are highly susceptible to developing various aggressive tumors throughout the body.
Affected dogs often develop aggressive cancers, such as bone cancer or lymphoma, typically at a young or middle age. Owners may notice signs such as persistent lameness, unusual swellings, unexplained weight loss, or a sudden drop in energy levels.
While the genetic predisposition itself cannot be cured, the resulting tumors are managed with intensive treatments like surgery or chemotherapy to extend the dog's life. These complex medical interventions are costly, with typical treatment expenses ranging from €3,000 to €10,000.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.