Leukocyte Adhesion Deficiency Type III · LAD3 · Canine LAD III · FERMT3 deficiency · Leukozytenadhäsionsdefekt Typ III · Leukozyten Adhäsionsdefizienz Typ III (Deutscher Schäferhund) · Canine Leukocyte Adhesion Deficiency Type III · LAD-III · Leukozyten-Adhäsionsdefizienz Typ 3 · FERMT3-Defizienz · Leukocyte Adhesion Deficiency Type 3
Leukocyte Adhesion Deficiency Type III (LAD III) is an inherited disorder affecting both white blood cells and platelets, which are crucial components of the immune and blood-clotting systems. In affected dogs, a genetic defect prevents these cells from sticking to blood vessel walls, meaning white blood cells cannot reach infections and platelets cannot form clots. This dual defect leads to both severe, recurrent infections and a dangerous inability to stop bleeding.
Symptoms typically appear within the first few weeks of a puppy's life. Owners will notice slow-healing wounds, gum inflammation, recurrent infections, and severe, prolonged bleeding from minor cuts or during teething.
There is no cure for this condition, and it is unfortunately fatal at a young age. Supportive care, including intensive antibiotics and transfusions, can help manage symptoms temporarily and typically costs between 2,000 and 7,000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.