Trapped Neutrophil Syndrom · Neutrophilensyndrom · VPS13B-Defizienz · Border Collie Immunschwäche · Trapped Neutrophil Syndrome (Border Collie) · TNS Border Collie · VPS13B mutation · Border Collie immunodeficiency · Neutrophilensequestrierung
Trapped Neutrophil Syndrome (TNS) is an inherited immune system disorder where the bone marrow produces white blood cells, called neutrophils, but is unable to release them into the bloodstream. Because these neutrophils are essential for fighting off bacteria and viruses, their absence leaves the dog's body highly vulnerable to infections. This genetic defect is inherited in an autosomal-recessive manner, meaning a puppy must receive the mutated gene from both parents to develop the condition.
Symptoms typically appear in puppies within the first few weeks to months of life. Owners will usually notice chronic, recurring infections that do not heal properly, accompanied by fever, joint pain, and a general failure to grow at a normal rate.
There is no cure for this severe condition, and therapy is limited to lifelong supportive care and antibiotics to manage infections. This ongoing medical management is generally unsuccessful long-term and typically costs between 1,000 and 5,000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.