Labradoodle (Labrador x Poodle)
Centronuclear Myopathy 2 · BIN1-related centronuclear myopathy · BIN1-CNM · Centronukleäre Myopathie Typ 2 · Centronuclear Myopathy Great Dane · CNM Great Dane · Inherited Myopathy of Great Danes · BIN1-related myopathy · Zentronukleäre Myopathie der Deutschen Dogge · Centronuclear Myopathy Great Dane Type
Centronuclear myopathy 2, also known as IMGD, is an inherited muscle disorder caused by a genetic defect in the BIN1 gene. This mutation disrupts the normal structure of muscle fibers, which are the microscopic building blocks of skeletal muscles. Because these fibers cannot contract properly, the dog's muscles progressively weaken and waste away.
Symptoms typically appear during puppyhood, usually between 2 and 6 months of age. Owners will likely notice muscle weakness, a stiff or bunny-hopping gait, rapid fatigue, and visible muscle wasting.
There is no cure for this condition, meaning treatment is limited to lifelong supportive care, including physiotherapy and lifestyle adjustments. The estimated lifetime cost for managing this disease ranges from 2,000 to 8,000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Ears.