Galaktosialidose · PPCA deficiency · Protective Protein Cathepsin A deficiency · Lysosomal storage disease galactosialidosis
Galactosialidosis is a severe lysosomal storage disease where a deficiency in a protective protein called cathepsin A causes essential cellular enzymes to fail. This failure prevents cells from breaking down waste, leading to a toxic buildup that progressively damages the nervous system and internal organs. Because the specific genetic mutation in dogs has not yet been characterized, no commercial DNA test is currently available.
Symptoms typically appear in early puppyhood and include progressive muscle weakness, difficulty coordinating movements, vision loss, and cognitive decline. The condition worsens rapidly, usually leading to death within a few months of onset.
There is no cure for this fatal disease, meaning veterinary care is limited to supportive and palliative comfort measures. Managing the dog's quality of life and pursuing diagnostic testing typically costs between 500 and 2500 EUR.
More conditions affecting the General / metabolic.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.