Glutathione S-transferase theta 1 deficiency · GSTT1 deficiency · GST-theta deficiency · Glutathione S-transferase theta activity · GSTT1-like variant
This genetic variation reduces the activity of the GST-theta enzyme, which is part of the liver's metabolic system. This enzyme is responsible for breaking down and neutralizing environmental toxins and certain medications. Without fully functioning enzymes, the dog's body may process these substances more slowly than normal.
Affected dogs typically show no outward symptoms in their daily lives. However, adverse reactions or signs of liver stress may become apparent at any age if the dog is exposed to specific medications or environmental toxins.
There is no direct treatment to restore enzyme activity, so management focuses on avoiding known toxic triggers and carefully selecting medications. This lifelong preventative approach is highly effective and carries minimal costs, typically ranging from 0 to 500 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.