APOE-related hyperlipidemia · Apolipoprotein E deficiency · Canine atherosclerosis · Hyperlipidaemia and atherosclerosis · APOE-Defizienz
This condition is a genetic disorder of the metabolic and cardiovascular systems where a defect in the apolipoprotein E (APOE) protein prevents the normal clearance of fats from the blood. This results in severely elevated cholesterol levels, which can lead to fatty deposits in the blood vessels, a process known as atherosclerosis. Currently, this genetic defect is only known as an engineered research model, with no naturally occurring cases reported in domestic dogs.
Based on the disease mechanism, affected dogs could show signs like lethargy, vomiting, abdominal pain from pancreas inflammation, or yellowish fatty skin nodules. These symptoms would typically appear during young to middle adulthood.
If treated, the condition requires lifelong management with a strict low-fat diet, regular veterinary monitoring, and potentially lipid-lowering medications. Ongoing care is estimated to cost between €2,000 and €7,000.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.