Hyperlipidaemia/atherosclerosis, APOE-related
Also known as: APOE-related hyperlipidemia · Apolipoprotein E deficiency · Canine atherosclerosis · Hyperlipidaemia and atherosclerosis · APOE-Defizienz
Overview
What it is
This condition is a genetic disorder of the metabolic and cardiovascular systems where a defect in the apolipoprotein E (APOE) protein prevents the normal clearance of fats from the blood. This results in severely elevated cholesterol levels, which can lead to fatty deposits in the blood vessels, a process known as atherosclerosis. Currently, this genetic defect is only known as an engineered research model, with no naturally occurring cases reported in domestic dogs.
How it presents
Because no natural cases have been documented in domestic dogs, there are no known symptoms or typical age of onset. Laboratory tests show extremely elevated blood fat levels.
Treatment
If treated, the condition requires lifelong management with a strict low-fat diet, regular veterinary monitoring, and potentially lipid-lowering medications. Ongoing care is estimated to cost between €2,000 and €7,000.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment costs. Actual costs depend on severity, clinic and region.
Frequently asked questions
What is Hyperlipidaemia/atherosclerosis, APOE-related?
This condition is a genetic disorder of the metabolic and cardiovascular systems where a defect in the apolipoprotein E (APOE) protein prevents the normal clearance of fats from the blood. This results in severely elevated cholesterol levels, which can lead to fatty deposits in the blood vessels, a process known as atherosclerosis. Currently, this genetic defect is only known as an engineered research model, with no naturally occurring cases reported in domestic dogs.
How is Hyperlipidaemia/atherosclerosis, APOE-related tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.