Hypophosphatasie · ALPL deficiency · Tissue-nonspecific alkaline phosphatase deficiency · Alkalische-Phosphatase-Mangel
Hypophosphatasia is a severe, inherited metabolic bone disease caused by a deficiency in the alkaline phosphatase enzyme, which is crucial for hardening skeletal tissues. Without enough of this enzyme, the dog's body cannot properly deposit minerals like calcium and phosphorus into its bones and teeth. This leads to abnormally soft, weak bones and skeletal structure.
Symptoms typically appear shortly after birth or during early puppyhood. Owners will notice severe bone deformities, extreme bone softness, stunted growth, and potentially seizures.
There is no cure for this condition, and it is unfortunately fatal during puppyhood. Veterinary care is limited to diagnostics and palliative support to keep the puppy comfortable, with costs typically ranging from 500 to 2500 EUR.
More conditions affecting the General / metabolic.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.