KRT1-Ichthyose · Keratin-1-Ichthyose · Congenital Ichthyosis KRT1 · KRT1-related non-epidermolytic ichthyosis · Non-epidermolytic ichthyosis, KRT1-related
This is an inherited skin condition caused by a genetic mutation in the KRT1 gene, which affects how the outer layer of the skin forms. In healthy dogs, keratin proteins provide structure to the skin, but this defect disrupts the normal shedding process, leading to a compromised skin barrier. Unlike the human version of this disease, the canine form does not cause the skin cells to break apart or blister.
Symptoms typically appear during puppyhood, presenting as large, dark scales, rough skin, and thickened paw pads. Owners may also notice their dog itching frequently or developing secondary skin infections.
While the condition is lifelong and incurable, it can be managed with ongoing supportive care such as specialized baths and topical treatments. Lifetime management costs for this moderate condition typically range from 1,500 to 5,000 EUR.
More conditions affecting the Skin & coat.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.