American Leopard Hound
Der bessere Weg, deinen Hund zu finden
Merle-Faktor · M-Lokus · PMEL gene mutation · Dapple gene · Merle Ocular Dysgenesis · Homozygous Merle ocular defects · Merle-Syndrom · Double-Merle-Augendysgenesie · Coat colour, merle
The merle coat pattern is caused by an autosomal-dominant mutation in the PMEL gene, which affects pigment-producing cells in the skin, eyes, and inner ears. When a dog inherits two copies of this gene, a condition known as double merle, it disrupts the normal development of these sensory organs. This genetic defect can lead to severe structural abnormalities in both the auditory and visual systems.
Double merle puppies are typically born with an excessively white coat and may show signs of partial or complete deafness and vision impairment from birth or early puppyhood. Owners may notice that the dog does not respond to sounds, has abnormally small or misshapen eyes, or struggles to navigate its environment.
The genetic deafness and blindness associated with this condition are incurable, requiring lifelong supportive care, specialized training, and regular veterinary monitoring. Managing these sensory deficits and associated eye conditions typically costs between 1,000 and 6,000 EUR over the dog's lifetime.
More conditions affecting the Skin & coat.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
