NIPAL4-related ichthyosis · Autosomal Recessive Congenital Ichthyosis · ARCI · Ichthyose (NIPAL4-Gen) · NIPAL4 Ichthyosis · Ichthyose der Amerikanischen Bulldogge · Nicht-epidermolytische Ichthyose · Hautverhornungsstörung
This form of ichthyosis is an inherited skin disorder caused by a genetic mutation in the NIPAL4 gene, which impairs the skin's outer protective barrier. Without a properly functioning barrier, the skin cannot regulate moisture or shed dead cells correctly, leading to a buildup of dry, scaly tissue. This disruption in the normal skin-renewal process is known as abnormal keratinization.
Owners will typically notice symptoms in young puppies, which present as severe skin scaling, roughness, redness, and frequent itching. Affected dogs are also highly prone to secondary bacterial or yeast skin infections due to the compromised skin barrier.
While there is no cure, the condition is manageable with lifelong, daily care including specialized medicated shampoos, rinses, and moisturizing treatments. Managing this chronic condition over a dog's lifetime typically costs between 2,000 and 8,000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Skin & coat.