TGM1-Ichthyose · Autosomal Recessive Congenital Ichthyosis · Transglutaminase-1 Deficiency · Congenital Ichthyosis TGM1-related · Jack Russell Terrier Ichthyosis
This is an inherited skin disorder caused by a genetic mutation in the TGM1 gene, which produces an enzyme essential for building the skin's outer protective barrier. Without this functioning enzyme, the skin cannot retain moisture or shed dead cells properly, leading to severe and uncontrolled scaling. This condition is also known as lamellar ichthyosis.
Owners will typically notice symptoms shortly after birth or during early puppyhood, characterized by large, dark, plate-like scales and extremely dry skin. The skin may also develop painful cracks or fissures that are highly prone to secondary bacterial infections.
There is no cure for this condition, meaning affected dogs require lifelong daily management with specialized topical treatments, moisturizing rinses, and frequent veterinary monitoring. Managing this chronic skin disease is estimated to cost between 3,000 and 8,000 EUR over the dog's lifetime.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Skin & coat.