CARD9 deficiency · CARD9-Defizienz · Caspase recruitment domain-containing protein 9 deficiency · CARD9-related immunodeficiency · Familiäre CARD9-Defizienz · Mycobacterium avium complex sensitivity · MAC susceptibility · Mycobacterium avium complex susceptibility
This is an inherited immune system disorder where a genetic defect impairs the CARD9 protein, preventing the body from effectively fighting off fungal pathogens and certain bacteria like Mycobacterium avium complex (MAC). Because the immune system cannot control these common environmental organisms, they can spread unchecked and cause severe damage to internal organs, bones, and skin.
The condition typically becomes apparent in young dogs, presenting as chronic, slow-healing infections of the skin, bones, or internal organs. Owners may observe persistent fever, swollen lymph nodes, lethargy, and progressive weight loss.
There is no cure, and affected dogs require lifelong, intensive medical management with specialized medications. This supportive care is costly, with typical lifetime treatment expenses ranging from €3,000 to €12,000, and the long-term prognosis remains poor.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.