Brazilian Terrier
Canine Malignant Hyperthermia · Maligne Hyperthermie Syndrom · MHS · RYR1-related hyperthermia · Maligne Hyperthermie · Anesthetic Hypersensitivity · Anesthetic Sensitivity · RYR1-Defekt · Narkoseüberempfindlichkeit
Malignant hyperthermia, also known as Narkoseüberempfindlichkeit, is an inherited skeletal muscle disorder caused by a genetic mutation in the RYR1 gene. This mutation disrupts how calcium is regulated within the muscle cells, causing them to contract uncontrollably when triggered. These intense spasms generate a rapid, life-threatening rise in body temperature, typically brought on by specific anesthetic gases or extreme physical stress.
Symptoms can emerge at any age, most commonly during general anesthesia or periods of intense physical exertion. An owner or veterinarian will notice sudden muscle stiffness, a racing heartbeat, rapid breathing, and a dangerously high fever.
An acute crisis is a severe medical emergency requiring immediate intensive care, with treatment costs typically ranging from 1,000 to 4,000 EUR. While the underlying genetic condition is lifelong, it is managed preventatively by avoiding known trigger anesthetics and minimizing extreme stress.
More conditions affecting the General / metabolic.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
