Mucopolysaccharidosis Type IIIA · Sanfilippo Syndrome A · Sanfilippo-Syndrom Typ A · MPS3A · Heparan Sulfate Sulfamidase Deficiency · SGSH Deficiency
Mucopolysaccharidosis IIIA is an inherited metabolic disorder where the body lacks a specific enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up to toxic levels inside cells, causing progressive and irreversible damage to the central nervous system, particularly the brain.
Symptoms typically appear between 1 and 3 years of age, starting with mild coordination issues or tremors. Over time, owners will notice more severe signs such as personality changes, disorientation, and progressive difficulty moving.
This condition is incurable, meaning treatment is lifelong and focused entirely on supportive care and pain management. Palliative veterinary care to keep the dog comfortable typically costs between 500 and 2000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.