Beagle
Mandated by AKC CHIC
Musladin-Lueke-Syndrom · Chinese Beagle Syndrome · Beagle Hereditary Connective Tissue Disorder · MLS-Syndrom · Geleophysic dysplasia, ADMATSL2-related · Geleophysic Dysplasia 1 · ADAMTSL2-related geleophysic dysplasia · Beagle MLS
Musladin-Lueke Syndrome (MLS) is an inherited connective tissue disorder that primarily affects Beagles. It is caused by a genetic mutation that leads to an abnormal buildup of collagen, which is the main structural protein in the body's supportive tissues. This buildup causes the skin, joints, and muscles to become abnormally stiff and hard.
Owners typically notice symptoms in puppies between 2 and 4 weeks of age. Affected dogs develop a stiff, upright "toe-walking" gait, unusually tight or thick skin, and distinctively slanted, creased eyes.
There is no cure for MLS, but the condition is manageable through lifelong supportive care, including physical therapy and pain management. Owners should expect ongoing veterinary and therapeutic costs ranging from 1,500 to 6,000 EUR over the dog's lifetime.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Skin & coat.