Plasminogen activator inhibitor-1 deficiency, SERPINE1-related(PAI-1)
PAI-1 deficiency · Plasminogenaktivator-Inhibitor-1-Mangel · SERPINE1 deficiency · SERPINE1-related bleeding disorder · Hyperfibrinolysis due to PAI-1 deficiency
What it is
This is an inherited bleeding disorder affecting the blood circulatory system, specifically how the body stabilizes blood clots. It is caused by a deficiency in a protein called plasminogen activator inhibitor-1 (PAI-1), which normally stops clots from dissolving too quickly. Without enough PAI-1, the body breaks down blood clots prematurely, leading to impaired clotting.
How it presents
Affected dogs usually show no symptoms in their daily lives and appear completely healthy. However, they will experience severe, delayed, and prolonged bleeding hours or days after undergoing a surgery, dental work, or sustaining an injury, which can first be noticed at any age when their first procedure occurs.
Treatment
The condition is not curable, but it can be managed successfully using specific clot-stabilizing medications before and after scheduled surgeries. Treatment is only needed on an as-needed basis around medical procedures rather than as a lifelong daily therapy, with costs ranging from 500 to 3000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.