Autoimmune Polyendocrine Syndrome · Polyglandular Autoimmune Syndrome · Polyglanduläres Autoimmunsyndrom · Canine Polyglandular Syndrome
Polyendocrine syndrome is a severe autoimmune disorder where the dog's immune system mistakenly targets and destroys multiple hormone-producing (endocrine) glands, either at the same time or one after another. This can damage critical organs like the adrenal glands, thyroid, and pancreas, leading to a failure in hormone production. Because the disease is complex and multifactorial, there are currently no direct genetic tests available.
Symptoms typically appear in young to middle-aged dogs and vary depending on which glands are damaged. Owners may notice signs such as extreme weakness, vomiting, increased thirst, weight loss, or sudden collapse.
This condition is incurable and requires lifelong, complex hormone replacement therapy alongside regular veterinary monitoring. Managing this disease is highly cost-intensive, with lifetime treatment costs typically ranging from 5,000 to 15,000 EUR.
More conditions affecting the General / metabolic.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.