RBCK1-related polyglucosan body myopathy · Polyglucosan-Körper-Myopathie · RBCK1 myopathy · Polyglucosan storage disease
This is an inherited muscle disorder where abnormal sugar molecules, known as polyglucosan bodies, build up inside the dog's muscle cells. This accumulation causes progressive damage to the skeletal muscles and can also affect the heart muscle. The condition is linked to a genetic mutation in the RBCK1 gene, which was recently characterized in Basset Hounds.
Affected dogs typically begin showing signs in young to middle age, presenting with progressive muscle weakness, stiffness, and muscle loss. Owners may also notice a reluctance to exercise and, as the disease advances, signs of heart dysfunction.
There is no cure for this progressive condition, meaning treatment is limited to lifelong supportive care to manage symptoms. Managing this disease typically incurs ongoing veterinary costs ranging from 1,500 to 6,000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the General / metabolic.