Eurasier
S Locus · Piebald locus · White spotting · MITF gene · Scheckungs-Lokus · Scheckung · Piebald spotting · MITF gene mutation · Extreme white spotting · Weißscheckung
The S-locus is a genetic region controlled by the MITF gene that regulates how pigment-producing cells distribute across a dog's skin and coat. When a dog inherits two copies of this recessive variant, it prevents pigment from developing in certain areas, resulting in white patches of fur and skin. This primarily affects the integumentary system (the skin and hair), but can occasionally impact the inner ear's pigment cells, which are vital for normal hearing.
Owners will notice white patches on the coat from birth, which can range from minor markings to an almost entirely white coat. If the lack of pigment extends to the inner ear, congenital deafness may be present and noticeable from puppyhood.
The coat variation itself requires no treatment, but dogs with extensive white skin may need lifelong sun protection, and deaf dogs require specialized training, with typical management costs ranging from 0 to 500 EUR.
More conditions affecting the Skin & coat.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.