Autoimmune lymphoproliferative syndrome, FAS-related(ALPS)
Autoimmunes lymphoproliferatives Syndrom · Canine autoimmune lymphoproliferative syndrome · FAS-deficient ALPS · FAS-assoziiertes ALPS · Canine ALPS · FAS-associated canine autoimmune lymphoproliferative syndrome
What it is
This is an inherited disorder of the immune system where the body fails to properly regulate and remove excess white blood cells. Because these cells do not break down as they normally should, they accumulate and overload the lymphatic system, which includes the lymph nodes and spleen. This buildup triggers severe autoimmune reactions, causing the dog's immune system to mistakenly attack its own healthy tissues.
How it presents
Symptoms typically appear in puppies or young dogs and include visibly swollen lymph nodes, an enlarged abdomen due to a swollen spleen, chronic fever, and lethargy. Owners may also notice pale gums and weakness caused by severe anemia.
Treatment
The condition is incurable and requires lifelong, intensive medical management using immunosuppressive drugs and frequent blood monitoring. Lifetime treatment costs are high, typically ranging from €3,000 to €12,000.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.