SevereGeneral / metabolicAutosomal recessiveAffects 19 breeds

Familial Nephropathy(FN)

Also known as: Hereditary Nephropathy · Alport Syndrome · Familiäre Nierenerkrankung · Familiäre Nephropathie · HN · …

What it is

Familial Nephropathy (FN) is an inherited kidney disease caused by a genetic defect in collagen, which is a vital structural protein. This defect damages the kidneys' filtering units, preventing them from properly removing waste products from the blood. Over time, this leads to progressive and irreversible kidney failure.

How it presents

Affected dogs typically show symptoms between 6 months and 2 years of age. Owners may notice signs of kidney dysfunction, such as excessive thirst, frequent urination, weight loss, vomiting, and general weakness.

Treatment

The disease is incurable and ultimately fatal, though supportive therapy can manage symptoms and maintain comfort. Managing this condition typically costs between 1,000 and 4,000 EUR.

How it's tested

Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA test
Rassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Protein-Losing-Nephropathy (PLN) DNA-Test(PLN)
Primary testDNA test
Der DNA-Test identifiziert Risikovarianten in den Genen NPHS1 und KIRREL2, die maßgeblich mit der Entstehung der Protein-Losing-Nephropathie beim Soft Coated Wheaten Terrier assoziiert sind.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Familiäre Nephropathie (FN) DNA-Test(FN)
Primary testDNA test
Ein Gentest, der die Mutation im COL4A4-Gen nachweist, welche für die Entstehung der familiären Nephropathie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA test
Rassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA test
US-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA test
Genoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected

Affected breeds

19 of 19 breeds

Treatment cost

€1,000 – €4,000

Estimated range of typical treatment costs. Actual costs depend on severity, clinic and region.

Frequently asked questions

What is Familial Nephropathy?

How is Familial Nephropathy tested?

Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Protein-Losing-Nephropathy (PLN) DNA-Test, Familiäre Nephropathie (FN) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.

Which breeds are most affected?

Most commonly affected: Cocker Spaniel, Bernese Mountain Dog, Bull Terrier, Cockapoo, Corgipoo, Dobermann, Irish Soft Coated Wheaten Terrier, Lhasa Apso.

How it's tested

Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)

Primary testDNA test

Rassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.

Issuing body: Labogen