Progressive Retinal Atrophy (PRA), autosomal dominant, RHO-related(adPRA)
Autosomal dominant progressive retinal atrophy · RHO-PRA · Rhodopsin-related progressive retinal atrophy · RHO-adPRA · AD-PRA · Dominant PRA in Mastiffs · Rhodopsin-PRA · Retinal atrophy, progressive, autosomal dominant, RHO-related
What it is
This is an inherited eye disease where a genetic defect in the rhodopsin (RHO) gene causes the light-sensitive cells in the retina to slowly break down and die. The retina is the layer at the back of the eye responsible for capturing light and sending visual signals to the brain. Because this degeneration is progressive, it leads to a gradual and permanent loss of vision.
How it presents
Owners typically first notice signs of night blindness, such as hesitation or bumping into objects in the dark, during early to middle adulthood. Over time, this vision loss progresses to complete blindness in both daylight and low light.
Treatment
There is no cure for this condition, but it is painless for the dog. Lifelong management focuses on regular veterinary eye exams and supportive care, with typical costs ranging from 500 to 2,500 EUR over the dog's lifetime.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.