Cone-rod dystrophy 3 (crd3)(crd3)
Also known as: Cone-rod dystrophy 3 · Progressive Retinal Atrophy crd3 · ADAM9-PRA · Cone-rod dystrophy Glen of Imaal Terrier type · crd3-PRA · …
Overview
What it is
This is an inherited eye disorder caused by a genetic mutation that affects the Glen of Imaal Terrier. It causes the progressive degeneration of photoreceptors, which are the light-sensitive cells in the retina at the back of the eye. Specifically, both the cones (responsible for bright light and color vision) and the rods (responsible for dim light vision) break down, leading to permanent vision loss.
How it presents
Owners typically notice initial signs such as night blindness or sensitivity to bright light when the dog is between 1 and 3 years of age. The condition gradually worsens, often leading to complete blindness by middle age.
Treatment
There is no cure for this progressive condition, and treatment is limited to supportive care and helping the dog adapt to vision loss. Lifetime veterinary monitoring and environmental aids typically cost between 300 and 1,500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment costs. Actual costs depend on severity, clinic and region.
Frequently asked questions
What is Cone-rod dystrophy 3 (crd3)?
This is an inherited eye disorder caused by a genetic mutation that affects the Glen of Imaal Terrier. It causes the progressive degeneration of photoreceptors, which are the light-sensitive cells in the retina at the back of the eye. Specifically, both the cones (responsible for bright light and color vision) and the rods (responsible for dim light vision) break down, leading to permanent vision loss.
How is Cone-rod dystrophy 3 (crd3) tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Irish Glen of Imaal Terrier.