GFAP-related leukodystrophy · Alexander-Krankheit · Glial Fibrillary Acidic Protein Mutation · GFAP-related Alexander Disease · Leukodystrophie beim Labrador
Alexander disease is a progressive genetic disorder affecting the central nervous system, specifically the brain and spinal cord. It is caused by a malformation of the myelin sheath, which is the protective coating that insulates nerve fibers and allows signals to travel properly. Without this healthy insulation, the nervous system cannot transmit messages correctly, leading to severe neurological decline.
Symptoms typically appear in puppies or young adults and include coordination issues, muscle weakness, stiffness, and rapidly worsening paralysis. Owners may first notice a clumsy gait or difficulty standing up.
There is no cure for this condition, and treatment is limited to supportive care to keep the dog comfortable. Managing symptoms and diagnostic testing typically cost between 500 and 2500 EUR.
More conditions affecting the Head / nervous system.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.