Leonberger
Mandated by Deutscher Club für Leonberger Hunde e.V.
Krabbe disease · Galactosylceramidase deficiency · GALC deficiency · Globoidzell-Leukodystrophie · Krabbe-Krankheit · Globoid Cell Leukodystrophy · Leukodystrophie · Myelindegeneration · White Matter Disease · Leukodystrophy · Standard Schnauzer Leukodystrophy · Hereditäre Leukodystrophie · Canine Leukodystrophy
Globoid cell leukodystrophy is an inherited metabolic disorder affecting the nervous system, caused by a deficiency in an essential enzyme. This deficiency leads to the buildup of harmful substances that destroy myelin, which is the protective sheath surrounding nerve fibers in the brain and spinal cord. Without this protective covering, the nerves cannot transmit signals properly, resulting in progressive neurological decline.
Symptoms typically begin between 3 and 6 months of age, starting with tremors, muscle weakness, a stiff gait, and poor coordination. As the disease worsens, it progresses to paralysis, behavioral changes, and blindness.
There is no cure for this fatal condition, and treatment is limited to supportive care and diagnostic confirmation. Managing the dog's comfort and confirming the diagnosis typically costs between 500 and 2000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Head / nervous system.
