Griscelli Syndrome · Griscelli-like Syndrome · Dilute with neurological defects · MYO5A-associated neurological syndrome · Griscelli-Syndrom · Dilute coat color with neurological defects · CDN · Coat Colour Dilution and Neurological Defects · Griscelli Syndrome Type 1
This severe genetic disorder affects both the nervous system and pigment production, serving as the canine equivalent of human Griscelli Syndrome Type 1. It is caused by a mutation in the MYO5A gene, which disrupts how cells transport pigment and support normal nerve function. This dual impact results in a lighter coat color alongside progressive neurological decline.
Affected puppies are born with a diluted coat color and typically develop severe neurological symptoms within their first few weeks of life. Owners will notice involuntary body tremors, seizures, and a significant lack of coordination when the puppy tries to move.
This condition is currently incurable, and management is limited to diagnostic testing and palliative care, which typically costs between 300 and 1500 EUR. Due to the rapid and severe decline in quality of life, affected puppies are usually humanely euthanized.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Head / nervous system.