Sandhoff disease · GM2 gangliosidosis type II · Sandhoff-Krankheit · GM2-Gangliosidose Typ II · Hexosaminidase A and B deficiency
This is an inherited lysosomal storage disease affecting the nervous system, caused by a lack of vital enzymes. Without these enzymes, fatty substances called gangliosides build up to toxic levels inside the cells. This accumulation progressively damages the dog's brain and nerve cells.
Symptoms typically begin between 3 and 6 months of age, starting with tremors, coordination issues, and muscle weakness. These signs rapidly progress to blindness and an inability to move.
There is no cure for this fatal condition, and treatment is limited to supportive care to maintain comfort. Managing palliative care and eventual humane euthanasia typically costs between 500 and 2000 EUR.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Head / nervous system.