Lissencephaly
Also known as: Lissenzephalie · Smooth brain syndrome · Agyria · Agyrie · Cerebral lissencephaly · …
Overview
What it is
Lissencephaly is an inherited brain malformation where the cerebral cortex, which is the outer layer of the brain, fails to develop its normal folds and remains abnormally smooth. This genetic defect disrupts how nerve cells migrate during development, severely impairing the central nervous system's ability to process information.
How it presents
Symptoms typically appear in puppies between two and four months of age. Owners usually notice severe learning difficulties, coordination problems, blindness, and frequent, difficult-to-control seizures.
Treatment
This condition is incurable, and treatment is limited to lifelong supportive care to manage symptoms like seizures. Managing this care typically costs between 1,000 and 3,500 EUR.
How it's tested
Magnetresonanztomographie (MRT) des Gehirns(MRT)
Primary testClinical examDie Diagnose wird durch eine Magnetresonanztomographie (MRT) des Schädels gestellt, welche die Fehlbildung oder das Fehlen des Balkens (Corpus callosum) bildlich darstellt.
Issuing body: vet
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment costs. Actual costs depend on severity, clinic and region.
Frequently asked questions
What is Lissencephaly?
Lissencephaly is an inherited brain malformation where the cerebral cortex, which is the outer layer of the brain, fails to develop its normal folds and remains abnormally smooth. This genetic defect disrupts how nerve cells migrate during development, severely impairing the central nervous system's ability to process information.
How is Lissencephaly tested?
Tests currently in our database: Magnetresonanztomographie (MRT) des Gehirns, Embark Breed + Health Panel, MyDogDNA Panel, Feragen Komplettpaket (rassespezifisch), Labogen Komplettpaket (rassespezifisch).
Which breeds are most affected?
Most commonly affected: Irish Red Setter, Lhasa Apso.