Subacute necrotizing encephalopathy (Leigh syndrome)(SNE)
Subacute necrotizing encephalopathy · Leigh's disease · Leigh syndrome · Canine subacute necrotising encephalopathy · Leigh-Syndrom · NDUFS7-related Leigh syndrome · Subakute nekrotisierende Enzephalomyelopathie · Mitochondriale Enzephalopathie · Necrotising encephalopathy, subacute, of Leigh
What it is
This is a severe, inherited metabolic brain disorder where a genetic defect prevents nerve cells from producing enough energy. Without adequate energy, cells in the brain deteriorate and die, leading to progressive tissue damage. This process primarily affects the central nervous system, which controls basic bodily functions.
How it presents
Symptoms typically appear during puppyhood and include coordination problems, seizures, vision loss, and difficulty swallowing. These neurological signs tend to progress rapidly.
Treatment
The condition is incurable and fatal, with veterinary care focusing on diagnostics and palliative support to keep the dog comfortable. Managing these end-of-life or diagnostic needs typically costs between 500 and 2000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.