Neuronal Ceroid Lipofuscinosis 12 · NCL 12 · ATP13A2-related NCL · Neuronal Ceroid Lipofuscinosis Australian Cattle Dog type · Ceroid-Lipofuszinose Typ 12 · Neuronal Ceroid Lipofuscinosis 12 (Tibetan Terrier type) · Late-Onset Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis type 12 (NCL12) is a severe inherited metabolic disorder that affects the nervous system. It is caused by a genetic mutation that prevents cells from properly breaking down waste, leading to a harmful buildup of fatty pigments in the brain's nerve cells. This accumulation gradually damages and destroys these vital cells over time.
Symptoms typically appear between 1.5 and 2 years of age, starting with coordination problems, tremors, behavioral changes, and vision loss. These signs rapidly progress to severe mental and physical decline.
There is no cure for this condition, and treatment is limited to supportive care to manage symptoms and maintain comfort. Lifelong palliative care typically costs between 1,000 and 3,500 EUR before euthanasia becomes necessary.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Head / nervous system.