Paroxysmal Dystonia-Ataxia Syndrome (TNR-related)
Paroxysmal dystonia-ataxia · TNR-related paroxysmal dyskinesia · Tenascin-R mutation · Paroxysmale Dystonie und Ataxie · TNR-PADA · Dystonia-ataxia syndrome, paroxysmal, TNR-related · Paroxysmal Exercise-Induced Dyskinesia (PED) - Weimaraner · Paroxysmal exercise-induced dyskinesia
What it is
This is an inherited neurological disorder affecting the central nervous system, caused by a genetic mutation in the Tenascin-R (TNR) gene. This mutation disrupts normal communication between nerve cells, leading to sudden, temporary episodes of abnormal muscle tone and poor coordination. Between these episodes, the dog's nervous system functions normally, and they appear completely healthy.
How it presents
Owners typically notice sudden episodes of muscle stiffness, cramping, and a loss of balance starting during the dog's first or second year of life. These episodes, which can last from minutes to hours, are often triggered by stress or excitement, though the dog remains fully conscious throughout.
Treatment
There is no cure for this condition, but the frequency of episodes can be managed lifelong with stress reduction and sometimes anti-convulsant medications. The lifelong costs for veterinary diagnostics and medical management typically range from 1,500 to 5,000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.