ARHGEF10 polyneuropathy · ARHGEF10-related inherited polyneuropathy · ARHGEF10-associated polyneuropathy · Leonberger Polyneuropathy Type 1 · Leonberger Polyneuropathie Typ 1 · ARHGEF10-related polyneuropathy
This hereditary condition affects the peripheral nervous system, which consists of the nerves connecting the brain and spinal cord to the rest of the body. A genetic defect damages the myelin sheath, the protective outer covering of these nerves. This damage disrupts the electrical signals traveling between the brain and the muscles, leading to progressive weakness.
Symptoms typically appear in young adulthood and include an uncoordinated gait, weakness, and muscle wasting in the hind legs. Owners may also notice noisy breathing, coughing, or a change in bark due to paralysis of the larynx, or voice box.
There is no cure for this progressive disease, so treatment focuses on supportive care such as physical therapy to maintain mobility. Managing this lifelong condition typically costs between 1,500 and 5,000 EUR for supportive therapies and assistive equipment.
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
More conditions affecting the Head / nervous system.