Dog Diseases Database
Every hereditary and common canine condition — with tests, affected body regions, and the breeds where each shows up most.
Filters
- HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), NECAP1-related(PRA-NECAP1)
This genetic eye condition, also known as PRA5 or PRA-N, causes the light-sensitive cells of the retina at the back of the eye to slowly degenerate. Because of a defect in the NECAP1 gene, these cells cannot function properly and eventually die off. This gradual loss of retinal tissue leads to progressive and permanent blindness.
Tested via: Eye exam, DNA testView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), Whippet(PRA)
This is an inherited eye disease in Whippets caused by a genetic mutation in the CABP4 gene, which affects the light-sensitive cells of the retina at the back of the eye. Over time, these cells gradually degenerate and lose their ability to send visual signals to the brain, eventually leading to complete blindness. Because it is an autosomal-recessive condition, a dog must inherit the mutated gene from both parents to develop the disease.
Tested via: DNA testView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (SAG-related)(PRA-SAG)
This is an inherited eye disease where the retina, the light-sensitive layer at the back of the eye, gradually breaks down. It is caused by a genetic mutation in the SAG gene, which disrupts the normal function of proteins needed for vision. Over time, this defect leads to the progressive loss of the photoreceptor cells that detect light, eventually causing blindness.
Tested via: Eye exam, DNA testView details - HighEyesX-linked
Progressive Retinal Atrophy, CACNA1F-related(PRA-CACNA1F)
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. A genetic defect in the calcium channels of the eye's photoreceptor cells prevents them from working correctly, causing them to slowly waste away. This progressive degeneration gradually destroys the cells responsible for both night and day vision.
Tested via: Eye exam, DNA testView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, CNGA1-related(CNGA1-PRA)
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the dog's eye. A genetic mutation in the CNGA1 gene causes the photoreceptor cells, which detect light, to slowly degenerate and die. Over time, this progressive loss of cells prevents the eye from sending clear visual signals to the brain.
Tested via: Eye exam, DNA testView details - SevereEyesAutosomal recessive
Progressive Retinal Atrophy, Cone-rod dystrophy 1 (American Pit Bull Terrier)(PRA-crd1)
Progressive Retinal Atrophy (crd1) is an inherited eye disease that affects the retina, which is the light-sensitive layer at the back of the eye. In affected dogs, the specialized sensory cells responsible for both day vision (cones) and night vision (rods) degenerate prematurely and irreversibly. This gradual breakdown of cells eventually prevents the eye from sending visual signals to the brain.
Tested via: Eye exam, DNA testView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, Early Onset (Spanish Water Dog)(PRA-EO)
Early Onset Progressive Retinal Atrophy, also known as EOPRA, is an inherited eye disease that causes the light-sensitive layer at the back of the eye, called the retina, to waste away prematurely. Because it is an autosomal-recessive condition, a dog must inherit the mutated gene from both parents to develop the disease. Over time, this cellular degeneration prevents the eye from sending clear visual signals to the brain, resulting in progressive and permanent vision loss.
Tested via: Eye exam, DNA testView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, MERTK-related(PRA-MERTK)
This is an inherited eye disorder where the retina, which is the light-sensitive layer at the back of the eye, slowly degenerates due to a genetic mutation in the MERTK gene. This defect prevents the photoreceptor cells—the specialized cells that detect light—from recycling waste products properly, causing them to gradually die off. Over time, this progressive loss of cells leads to complete blindness.
Tested via: Eye exam, DNA testView details - SevereEyesAutosomal recessive
Progressive Retinal Atrophy, Miniature Schnauzer, type 1(PRA)
This is an inherited eye disease, also known as PRA B1, that affects Miniature Schnauzers. It causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye that sends visual signals to the brain. Over time, this progressive degeneration leads to complete vision loss.
Tested via: Eye exam, DNA testView details - HighEyesX-linked
Progressive Retinal Atrophy, Miniature Schnauzer, type 2(PRA-Type 2)
This is an inherited eye disease in Miniature Schnauzers where the retina, the light-sensitive layer at the back of the eye, gradually degenerates. Because the cells that detect light slowly die off, the dog's vision progressively worsens. There is currently no DNA test available for this specific Type 2 mutation, so diagnosis relies on clinical eye examinations by a veterinary ophthalmologist.
Tested via: Eye examView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, rod-cone dysplasia 3 (Cardigan Welsh Corgi)(PRA-rcd3)
Progressive Retinal Atrophy (rcd3) is an inherited eye disease affecting Cardigan Welsh Corgis, where the light-sensitive cells of the retina (the back part of the eye that processes images) fail to develop properly and gradually die off. This progressive degeneration disrupts the eye's ability to send visual signals to the brain, ultimately resulting in complete blindness.
Tested via: Eye exam, DNA testView details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, type 3, FAM161A-related(PRA3)
This is an inherited eye disease where the retina, the light-sensitive layer at the back of the eye, gradually breaks down. A genetic mutation in the FAM161A gene causes the progressive loss of photoreceptors, which are the specialized cells responsible for detecting light. Over time, this degeneration leads to irreversible vision loss.
Tested via: Eye exam, DNA testView details - SevereGeneral / metabolicUnknown
Progressive subacute myopathy
This is an extremely rare muscle disorder where the muscle fibers progressively break down and lose their strength over a relatively short period. It affects the musculoskeletal system, specifically the skeletal muscles that control voluntary movement. Because it is so rare, having only been documented in a single 1994 case report, the exact biological cause remains unknown.
View details - SevereGeneral / metabolicComplex
Prostate cancer(PCA)
Prostate cancer is a severe, malignant tumor originating in the prostate gland, which is part of the male reproductive system. Unlike in humans, this cancer develops regardless of whether a dog has been neutered. The tumor is highly aggressive, meaning it grows rapidly and frequently spreads, or metastasizes, to other parts of the body like the lymph nodes, lungs, and bones.
View details - SevereGeneral / metabolicUnknown
Pulmonary adenomatosis
Pulmonary adenomatosis is a rare, cancerous lung condition in dogs similar to bronchioloalveolar carcinoma, where cells in the deep lung tissues multiply uncontrollably. This abnormal cell growth gradually replaces healthy, functional lung tissue, severely reducing the dog's ability to absorb oxygen.
View details - SevereHeartComplex
Pulmonary hypertension(PH)
Pulmonary hypertension is abnormally high blood pressure in the blood vessels that supply the lungs. This increased pressure forces the right side of the heart to work much harder to pump blood, which can eventually lead to heart failure and poor oxygen delivery throughout the body. It usually develops as a secondary complication of an underlying heart or lung disease.
Tested via: Cardiac examView details - ModerateSkin & coatComplex
Pyoderma
Pyoderma is a bacterial infection of the skin, which is the body's primary protective organ system. It typically develops as a secondary condition when the skin's natural defenses are weakened by underlying issues such as allergies, parasites, or hormonal imbalances. This allows normal surface bacteria to multiply rapidly and cause localized inflammation.
View details - SevereGeneral / metabolicComplex
Pyometra, resistance/susceptibility to
This genetic predisposition influences a female dog's risk of developing pyometra, which is a severe, pus-filled infection of the uterus. The condition occurs when hormonal changes after a heat cycle make the uterine lining more vulnerable to bacterial invasion, affecting the reproductive system.
View details - SevereHead / nervous systemAutosomal recessive
Quadriplegia and amblyopia(QA)
This is a severe, inherited neurological disorder affecting the brain and nervous system. It leads to developmental abnormalities that cause paralysis in all four limbs, known as quadriplegia, alongside severe visual impairment, known as amblyopia. The condition is inherited in an autosomal-recessive manner, meaning a puppy must inherit the mutated gene from both parents.
View details - SevereHead / nervous systemAutosomal recessive
RALGAPA1-related cerebellar ataxia
Cerebellar ataxia (CA1) is an inherited neurological disease that affects the brain, specifically the cerebellum, which is the area responsible for coordinating movement and balance. A genetic mutation in the RALGAPA1 gene causes the cells in this part of the brain to progressively degenerate. This degeneration leads to a gradual loss of voluntary muscle control.
Tested via: DNA testView details - MildGeneral / metabolicComplex
Recombination rate
Recombination rate is a normal biological measure of how genetic material naturally shuffles and rearranges when eggs or sperm are formed. It is not a disease or a medical disorder, but rather a standard feature of how DNA is passed down to the next generation. This process occurs at the cellular level and does not negatively impact any organ system.
View details - MildEyesUnknown
Reduced cyclic guanosine monophosphate (cGMP) concentration
This is a benign genetic variation, or polymorphism, that affects how a dog processes certain medications like sildenafil rather than causing a physical disease. It involves a change in the PDE5A gene, which is related to cellular signaling pathways. This variation does not cause any organ damage or clinical illness.
View details - ModerateGeneral / metabolicComplex
Reduced exercise tolerance
Reduced exercise tolerance, or fitness problems, is a condition where a dog has a significantly decreased capacity for physical activity. This issue typically stems from underlying cardiovascular, respiratory, or musculoskeletal weaknesses that prevent the body from efficiently delivering oxygen to tissues during exertion. It is often influenced by a complex combination of genetic factors and anatomical structures.
View details - ModerateHipsAutosomal recessive
Reduced glutathione deficiency, unclassified(GSHD)
This condition is an inherited deficiency of reduced glutathione, which is a vital antioxidant that protects red blood cells from damage. Without enough of this protective molecule, the red blood cells are easily destroyed by oxidative stress, which is chemical damage caused by unstable molecules in the body.
View details - MildSkin & coatAutosomal recessive
Reduced hair shedding, MC5R-related
This is not a disease, but a genetic variation in the MC5R gene that affects the hair follicles, which are the specialized skin structures responsible for hair growth. This variation influences the hair cycle and sebum production, resulting in a coat that sheds significantly less. It is a completely benign physical trait that does not impact the dog's internal health or organ systems.
Tested via: DNA testView details
Frequently asked questions
What is the HonestDog dog diseases database?
Our database brings together hereditary and common canine conditions with symptoms, inheritance patterns, testing methods, and the breeds where each matters most.
How do I find the right test for a condition?
Search by disease name, abbreviation or symptom, then filter by test type, body region or severity. Each detail page lists recommended tests and affected breeds.
Why do health tests matter for breeders?
Health tests help catch hereditary conditions early and support responsible breeding. Many breed clubs require or recommend specific tests as part of their screening.
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