Dog Diseases Database
Every hereditary and common canine condition — with tests, affected body regions, and the breeds where each shows up most.
Filters
- HighEyesAutosomal dominant
Ocular melanosis(OM)
Ocular melanosis is an inherited eye condition where pigment-producing cells multiply abnormally within the eye. These dark pigment deposits can block the natural drainage pathways for eye fluid. This blockage leads to a dangerous buildup of pressure inside the eye, a painful condition known as glaucoma.
View details - HighGeneral / metabolicComplex
Ocular squamous cell carcinoma(OSCC)
Ocular squamous cell carcinoma is a malignant, or cancerous, tumor affecting the tissues around the eye, such as the eyelids, third eyelid, or the conjunctiva (the pink membrane lining the eyelids). It occurs when the flat skin cells in these areas grow uncontrollably, a process often triggered by ultraviolet light exposure, particularly in dogs lacking protective dark pigment around their eyes. Clinical screening, such as an ECVO eye examination, is used to identify early lesions on the eye surface.
View details - SevereGeneral / metabolicComplex
Omphalocele
An omphalocele is a severe congenital defect of the abdominal wall where the puppy's internal organs, such as the intestines, develop outside the body. These organs remain enclosed in a thin, translucent sac at the base of the umbilical cord. This occurs because the abdominal muscles fail to close properly during early embryonic development.
View details - ModerateGeneral / metabolicUnknown
Orchitis
Orchitis is an inflammatory condition of the testicles, which are key organs in the male reproductive system. It is usually caused by a bacterial infection or physical trauma to the area. If left untreated, this inflammation can damage the testicular tissue and lead to permanent infertility.
View details - MildGeneral / metabolicComplex
Osmotic resistance of erythrocytes(EOF)
This term refers to a physiological trait measuring how well red blood cells, also known as erythrocytes, tolerate changes in fluid pressure before rupturing. Rather than a primary disease, it is a subclinical hematological variation that describes the physical stability of these oxygen-carrying cells. It does not typically cause systemic illness or damage to any organ system on its own.
View details - HighMouth & teethUnknown
Osteochondromatosis, generic(MCE)
This is a genetic skeletal disorder where multiple benign, or non-cancerous, bony growths capped with cartilage develop on the surface of a dog's bones, ribs, or spine. These growths, called osteochondromas, occur due to abnormal bone development as the skeleton matures. The condition primarily impacts the skeletal system but can affect nearby nerves and blood vessels as the growths expand.
Tested via: DNA testView details - SevereGeneral / metabolicComplex
Osteosarcoma(OSA)
Osteosarcoma is an aggressive type of bone cancer that primarily affects the skeletal system of dogs. It causes abnormal, rapid cell growth that destroys healthy bone tissue, weakening the bone and making it prone to fractures. This cancer also has a high tendency to spread, or metastasize, to other parts of the body, particularly the lungs.
View details - SevereGeneral / metabolicUnknown
Otocephaly
Otocephaly is a rare developmental defect affecting the skeletal and respiratory systems of the head during embryonic growth. In this condition, the lower jaw fails to form properly and is either extremely underdeveloped or entirely missing, while the ears are abnormally positioned and fused low on the neck. Because these vital structures do not develop, the puppy's upper airway and mouth are severely compromised.
View details - ModerateGeneral / metabolicUnknown
Ovarian cysts
Ovarian cysts are fluid-filled sacs that develop on a female dog's ovaries, which are the reproductive organs responsible for producing eggs and hormones. These cysts typically stem from hormonal imbalances and can continuously release sex hormones into the body. This constant hormone production disrupts the dog's normal heat cycle and can negatively affect the uterine lining.
View details - HighSkin & coatAutosomal recessive
Palmoplantar hyperkeratosis, DSG1-related(PPK)
This is an inherited skin disorder caused by a genetic mutation that disrupts how skin cells bind to one another. Without proper cell adhesion, the outer layer of the skin becomes unstable, leading to an extreme thickening of the paw pads, a condition known as hyperkeratosis. This primarily affects the integrity of the dog's paw pads and skin barrier.
Tested via: DNA testView details - ModerateSkin & coatAutosomal recessive
Palmoplantar keratoderma, nonepidermolytic, focal 1(HFH)
This is a hereditary skin disorder that affects the paw pads, caused by a genetic mutation that disrupts how keratin, a protective protein in the skin, is produced. This disruption leads to an abnormal, extreme thickening of the outer layer of the paw pads. It is specifically known to affect the Dogue de Bordeaux breed.
View details - SevereHead / nervous systemAutosomal recessive
Parkinson disease, PARK7-related
This is a severe, inherited neurological disorder affecting the brain and nervous system. A genetic mutation in the PARK7 gene leads to the progressive loss of specialized nerve cells that are responsible for controlling and coordinating body movements. Over time, this cellular damage impairs the brain's ability to transmit smooth signals to the muscles.
View details - ModerateHead / nervous systemAutosomal recessive
Paroxysmal Dyskinesia, PCK2-related(PxD)
This is an inherited neurological disorder in Shetland Sheepdogs caused by a mutation in the PCK2 gene, which affects cellular energy metabolism. This genetic defect leads to sudden, temporary episodes of involuntary muscle movements and spasms while the dog remains fully conscious. Because it is an autosomal-dominant condition, a dog only needs to inherit one copy of the mutated gene from a parent to be at risk.
View details - SevereHead / nervous systemAutosomal recessive
Paroxysmal Dyskinesia, SOD1-related
This is an inherited neurological disorder affecting the nervous system, caused by a specific mutation in the SOD1 gene. It leads to temporary disruptions in the brain's motor control centers, resulting in sudden episodes of involuntary muscle movements. Between these episodes, the dog's nervous system functions normally and they appear completely healthy.
View details - HighHead / nervous systemAutosomal recessive
Paroxysmal Dystonia-Ataxia Syndrome (TNR-related)
This is an inherited neurological disorder affecting the central nervous system, caused by a genetic mutation in the Tenascin-R (TNR) gene. This mutation disrupts normal communication between nerve cells, leading to sudden, temporary episodes of abnormal muscle tone and poor coordination. Between these episodes, the dog's nervous system functions normally, and they appear completely healthy.
Tested via: DNA testView details - SevereHeartComplex
Patent ductus arteriosus and pulmonary hypertension(PDA)
This is a severe congenital heart defect where a blood vessel connecting the aorta and the pulmonary artery fails to close after birth. This failure causes high blood pressure in the lungs, known as pulmonary hypertension, which can eventually force oxygen-poor blood to flow backward into the body's main circulation. An echocardiogram, which is a specialized heart ultrasound, is the gold standard method used to diagnose this condition and evaluate the direction of blood flow.
View details - SevereHeartComplex
Patent ductus venosus(PDV)
Patent ductus venosus is a congenital defect of the circulatory and liver systems where a natural blood vessel that bypasses the liver during fetal development fails to close after birth. Because this vessel remains open, blood from the digestive tract bypasses the liver's filtration system, allowing toxins to circulate directly to the brain and other organs. This lack of filtration can lead to a state of self-poisoning known as hepatic encephalopathy.
View details - ModerateGeneral / metabolicUnknown
Patent urachus
A patent urachus is a birth defect affecting the urinary system where the temporary tube connecting an unborn puppy's bladder to the belly button, known as the umbilicus, fails to close before birth. Normally, this channel seals off completely, but when it remains open, it allows urine to leak from the navel. This creates an abnormal direct pathway between the bladder and the outside of the body.
View details - SevereGeneral / metabolicAutosomal recessive
PCYT2 deficiency(PCYT2)
PCYT2 deficiency is an inherited metabolic disorder affecting the nervous system and eyes, also known as progressive retinal, central, and peripheral neurodegeneration. A genetic defect impairs lipid (fat) metabolism, which leads to the progressive breakdown of nerve cells in the brain, peripheral nerves, and the retina (the light-sensitive tissue at the back of the eye). This disruption prevents normal cellular maintenance and leads to widespread neurological decline.
View details - HighGeneral / metabolicComplex
Pelvic organ prolapse, susceptibility to
This is a genetic predisposition where the connective tissues and muscles supporting the pelvic organs, such as the vagina or uterus, are abnormally weak. Because of this weakness, these organs can shift out of their normal positions and protrude outward, a process known as prolapse. This condition primarily affects the reproductive and urinary systems of female dogs.
View details - SevereHeartComplex
Pentalogy of Fallot(PoF)
Pentalogy of Fallot is a severe, complex heart defect present from birth that involves five distinct structural abnormalities in the heart and its main blood vessels. These malformations prevent the heart from pumping blood efficiently, causing oxygen-poor blood to circulate throughout the body instead of going to the lungs. This leads to a chronic lack of oxygen in the dog's tissues and organs.
View details - HighGeneral / metabolicComplex
Perineal hernia
A perineal hernia occurs when the muscles of the pelvic diaphragm weaken or tear, allowing pelvic organs and tissues like the bladder or intestines to push into the area next to the anus. This structural failure in the pelvic region can disrupt normal digestive and urinary functions. It is also commonly referred to as a Dammhernie.
View details - MildGeneral / metabolicAutosomal recessive
Persistence of immature pyruvate kinase and hexokinase isozymes
This is an inherited condition where a dog's red blood cells continue to produce immature, fetal versions of two key metabolic enzymes, pyruvate kinase and hexokinase, instead of transitioning to the mature adult forms. These enzymes are crucial for generating energy within red blood cells, which are the cells responsible for carrying oxygen throughout the body. Because these immature enzymes still function adequately, the overall health of the blood cells is preserved, making this a harmless and benign trait.
View details - ModerateGeneral / metabolicAutosomal recessive
Persistent Müllerian Duct Syndrome(PMDS)
Persistent Müllerian Duct Syndrome (PMDS) is a genetic disorder of the reproductive system in male dogs. It occurs when the internal female reproductive tract, including the uterus, fails to break down during embryonic development and remains present alongside male organs. Affected dogs are genetically male and typically have normal external male anatomy, but carry these hidden internal female structures.
View details - SevereHeartComplex
Persistent truncus arteriosus(PTA)
Persistent truncus arteriosus is a severe congenital heart defect where the two main blood vessels leaving the heart, the aorta and the pulmonary artery, fail to separate during embryonic development. This leaves a single large vessel carrying a mixture of oxygen-rich and oxygen-poor blood to both the body and the lungs. The resulting overload on the cardiovascular system prevents normal circulation and oxygen delivery.
View details
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