Dog Diseases Database
Every hereditary and common canine condition — with tests, affected body regions, and the breeds where each shows up most.
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- SevereSpineAutosomal recessive
Necrotising myelopathy, IBA57-related(HNM)
This condition, also known as hereditary necrotizing myelopathy (HNM), is a severe, recessively inherited disorder affecting the spinal cord. A genetic defect in the IBA57 gene leads to the progressive degeneration and death, or necrosis, of nerve tissue in the central nervous system. This loss of nerve tissue disrupts the communication between the brain and the rest of the body.
View details - SevereGeneral / metabolicAutosomal recessive
Nemaline Myopathy(NEM)
Nemaline Myopathy (NM) is a severe, inherited muscle disorder affecting the skeletal muscles. It is caused by an abnormal accumulation of thread-like protein structures, called nemaline rods, inside the muscle cells. This buildup disrupts the normal structure of the muscle fibers, preventing them from contracting properly and leading to widespread muscle weakness.
Tested via: DNA testView details - SevereHead / nervous systemAutosomal recessive
Neonatal Cerebellar Ataxia (GRM1-related)(BNAt)
This is an inherited neurological disorder that affects the cerebellum, which is the part of the brain responsible for coordinating movement. A genetic mutation in the GRM1 gene disrupts normal chemical signaling between brain cells from birth. This disruption prevents the brain from properly controlling muscle movements and balance.
View details - SevereGeneral / metabolicUnknown
Neonatal hepatitis
Neonatal hepatitis, also known in veterinary medicine as lobular dissecting hepatitis, is a severe inflammatory disease of the liver that affects very young puppies. In this condition, inflammation disrupts the normal structure of the liver tissue, which severely impairs the organ's ability to filter toxins and perform essential metabolic functions.
View details - SevereGeneral / metabolicComplex
Neonatal isoerythrolysis(NI)
This is an immune system disorder affecting newborn puppies where the mother's first milk, called colostrum, contains antibodies that attack and destroy the puppy's own red blood cells. This destruction of red blood cells, known as hemolysis, occurs because of incompatible blood types between the mother and her offspring. It rapidly deprives the puppy's body of oxygen and damages the circulatory system.
View details - SevereGeneral / metabolicComplex
Neoplasm, generic
A neoplasm is an abnormal and uncontrolled growth of cells that can form either benign, non-spreading tumors or malignant, cancerous tumors in any organ system of the body. This occurs when the body's normal cell regulation fails, allowing damaged cells to multiply instead of dying off. These growths can disrupt the function of surrounding healthy tissues and organs.
View details - SevereGeneral / metabolicUnknown
Nephronophthisis(NPHP)
Nephronophthisis is a severe kidney disease characterized by progressive scarring of the renal tubules, which are the tiny structures that filter waste from the blood. As the healthy kidney tissue is replaced by scar tissue, the kidneys gradually lose their ability to concentrate urine and filter toxins. While previously associated with specific genetic markers, the exact inheritance pattern in dogs is currently unknown.
View details - SevereHead / nervous systemAutosomal recessive
Neuroaxonal dystrophy, MFN2-related(NAD)
Neuroaxonal dystrophy (MFN2-related) is a severe, inherited neurological disorder that affects the nervous system of Giant Schnauzers and Schnauzer-Beagle crosses. It is caused by a genetic defect in the mitofusin-2 gene, which leads to abnormal swelling and progressive damage to the nerve fibers, known as axons, that transmit signals throughout the body. This damage prevents the brain and spinal cord from communicating properly with the muscles.
View details - SevereHead / nervous systemAutosomal recessive
Neuroaxonal dystrophy, PLA2G6-related(NAD)
This is a severe, inherited neurological disorder affecting the central nervous system, which includes the brain and spinal cord. It is caused by a genetic mutation that leads to abnormal swelling in the nerve fibers, known as axons, preventing proper communication between nerve cells. Over time, this swelling leads to the progressive degeneration of nerve tissue.
Tested via: DNA testView details - SevereHead / nervous systemAutosomal recessive
Neuroaxonal dystrophy, TECPR2-related(NAD)
This is a severe, inherited nervous system disorder caused by a genetic mutation in the TECPR2 gene. It leads to neuroaxonal dystrophy, a condition where the nerve fibers, or axons, in the brain and spinal cord swell and progressively degenerate. Because these damaged nerve cells cannot properly transmit signals, the dog's neurological function steadily declines.
Tested via: DNA testView details - HighHead / nervous systemUnknown
Neurofibromatosis(NF)
Neurofibromatosis is a rare disorder of the nervous system where tumors, called neurofibromas, grow along the dog's nerve pathways. These tumors, which can be benign (non-cancerous) or malignant (cancerous), cause damage by putting physical pressure on the nerves and surrounding organs.
View details - SevereHead / nervous systemAutosomal recessive
Neurological syndrome
This is a severe, inherited neurological disease affecting the brain and nervous system of Gordon Setter puppies, historically known by breeders as DUNGd. It is caused by an autosomal recessive genetic mutation that disrupts normal brain function, leading to fatal neurological decline.
View details - SevereHead / nervous systemAutosomal recessive
Neuronal Ceroid Lipofuscinosis 10 (American Bulldog)(NCL-10)
Neuronal Ceroid Lipofuscinosis Type 10 (NCL-10) is an inherited metabolic disorder that affects the central nervous system. Due to a genetic mutation, the dog's body lacks a vital enzyme needed to clear cellular waste, leading to a harmful buildup of fat-protein deposits inside the brain's nerve cells. Over time, this accumulation damages and destroys these cells, causing progressive neurological decline.
Tested via: DNA testView details - SevereHead / nervous systemAutosomal recessive
Neuronal Ceroid Lipofuscinosis 8 (Saluki)(NCL-8)
Neuronal Ceroid Lipofuscinosis type 8 (NCL8) is an inherited metabolic disorder that affects the dog's nervous system. It is caused by a genetic mutation that prevents cells from breaking down waste products, leading to a harmful buildup of fatty pigments inside nerve cells. Over time, this accumulation damages and destroys vital brain tissue.
Tested via: DNA testView details - SevereHead / nervous systemAutosomal recessive
Neuronal ceroid lipofuscinosis, 1(NCL1)
Neuronal ceroid lipofuscinosis type 1 (NCL1) is an inherited metabolic disorder that affects the nervous system. It is classified as a lysosomal storage disease, which means the cells' internal recycling centers (lysosomes) cannot properly break down waste. This leads to a harmful buildup of cellular debris in the nerve cells of the brain and eyes, causing progressive damage.
View details - SevereHead / nervous systemAutosomal recessive
Neuronal ceroid lipofuscinosis, 12(NCL12)
Neuronal ceroid lipofuscinosis type 12 (NCL12) is a severe inherited metabolic disorder that affects the nervous system. It is caused by a genetic mutation that prevents cells from properly breaking down waste, leading to a harmful buildup of fatty pigments in the brain's nerve cells. This accumulation gradually damages and destroys these vital cells over time.
View details - SevereHead / nervous systemAutosomal recessive
Neuronal ceroid lipofuscinosis, 2(NCL2)
Neuronal ceroid lipofuscinosis type 2 (NCL2) is an inherited metabolic disorder affecting the nervous system. It is caused by a deficiency in a specific enzyme, which prevents the body from breaking down cellular waste products. These waste materials build up inside the cells of the brain and the retina, the light-sensitive tissue at the back of the eye, leading to progressive cell death and severe neurological damage.
View details - SevereHead / nervous systemAutosomal recessive
Neuronal ceroid lipofuscinosis, 6(NCL6)
Neuronal ceroid lipofuscinosis type 6 (NCL6) is an inherited metabolic disorder that affects the nervous system. It occurs when the body fails to properly break down cellular waste, causing fatty pigments called lipofuscins to build up inside nerve cells. This accumulation gradually damages and destroys cells in the brain and other tissues.
View details - SevereHead / nervous systemAutosomal recessive
Neuronal ceroid lipofuscinosis, 8(NCL8)
Neuronal ceroid lipofuscinosis type 8 (NCL8) is an inherited metabolic disorder affecting the central nervous system. It is caused by a genetic defect that prevents cells from breaking down cellular waste products, leading to a harmful buildup in the brain's nerve cells. Over time, this accumulation causes progressive and irreversible damage to the brain tissue.
View details - SevereHead / nervous systemAutosomal recessive
Neuronal ceroid lipofuscinosis, type 5(NCL5)
Neuronal ceroid lipofuscinosis type 5 (NCL 5) is an inherited disorder that affects the dog's nervous system. It is classified as a lysosomal storage disease, which means the cells' natural recycling centers fail to break down waste products properly. This leads to a harmful buildup of fatty pigments in the brain cells, causing them to gradually break down and die.
View details - HighSkin & coatComplex
Neutrophilic dermatosis
This is a rare immune-mediated skin condition where a specific type of white blood cell, called a neutrophil, abnormally accumulates in the deep layers of the skin. This buildup causes severe inflammation and tissue damage without any actual underlying infection being present.
View details - SevereGeneral / metabolicAutosomal recessive
Niemann-Pick disease, type A(NPA)
Niemann-Pick disease type A is an inherited metabolic disorder where the lack of a vital enzyme prevents the body from breaking down certain fats. Because of this deficiency, these fats build up to toxic levels inside cells, primarily damaging the nervous system, liver, and spleen. This progressive accumulation leads to widespread cell damage and severe organ dysfunction.
View details - SevereHead / nervous systemAutosomal recessive
Niemann-Pick disease, type C1(NPC1)
Niemann-Pick disease type C1 is an inherited metabolic disorder where the body cannot properly process fats and cholesterol. This causes these fatty substances to build up inside cells, particularly within the brain and nervous system. Over time, this cellular accumulation leads to progressive and severe neurological damage.
View details - ModerateGeneral / metabolicAutosomal recessive
Nose, bifid, PDGFRA-related
This is a genetic developmental disorder affecting the respiratory system and facial structure, caused by a mutation in the PDGFRA gene. It results in a bifid nose, which means the nasal structure is split or divided down the middle into two halves. This condition is inherited in an autosomal-dominant pattern, meaning a puppy only needs to inherit one copy of the mutated gene from a single parent to show the trait.
View details - ModerateGeneral / metabolicComplex
Obesity
Obesity is a chronic metabolic disorder characterized by an excessive accumulation of body fat that affects the entire body. It is driven by a complex combination of genetic predisposition and an imbalance between energy intake and expenditure. Veterinarians use the Body Condition Score (BCS) clinical exam as the gold standard method to diagnose and monitor this condition.
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